Generating a novel and reliable human iPSC‐derived midbrain organoid model of sporadic progressive supranuclear palsy
Sporadic PSP patient hiPSCs reliably differentiate into midbrain dopaminergic organoids and astrocytes, resulting in a sporadic tauopathy model containing key cell types affected in PSP. This cell collection is a valuable resource to investigate candidate mechanisms underlying tauopathy and could provide insight into cell-type specific disease drivers.
Authors
- Ruth H. Walker (ORCID: https://orcid.org/0000-0002-8366-072X)
- Megan A. Iida
- Alessandra Cervera
- Kurt Farrell (ORCID: https://orcid.org/0000-0001-6955-7278)
- Tim Ahfeldt (ORCID: https://orcid.org/0000-0001-6377-7376)
- Thomas D. Christie
- Gustavo Morrone Parfitt (ORCID: https://orcid.org/0000-0003-0168-4099)
- Melissa J. Nirenberg (ORCID: https://orcid.org/0000-0003-3892-6733)
- Giulietta Riboldi (ORCID: https://orcid.org/0000-0003-0322-5718)
- Lily Sarrafha (ORCID: https://orcid.org/0000-0002-6168-2119)
- Margaret M. Krassner (ORCID: https://orcid.org/0009-0007-6443-2127)
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- SoongHo Kim
- Sally Temple (ORCID: https://orcid.org/0000-0001-7301-783X)
- Kristen Whitney (ORCID: https://orcid.org/0000-0002-1578-6339)
- Steven J. Frucht (ORCID: https://orcid.org/0000-0002-4653-0491)
- Sean Thomas Delica
- Claudia De Sanctis (ORCID: https://orcid.org/0000-0002-9318-7323)
- Grace A. Selecky
- Victoria Flores Almazan
Institutions
- Allen Institute for Brain Science (US)
- Neural Stem Cell Institute (US)
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093263
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37