pTau‐associated gene expression signatures in the middle temporal gyrus
Disentangling the relationship between cellular vulnerability and pathology is critical to understand early AD pathogenesis. By adopting a standardized cell taxonomy and integrating datasets, we refined the definition of vulnerable cells to distinguish highly resolved pTau-prone cell types and identified a pTau-specific gene expression signature in the MTG.
Authors
- Victoria M. Rachleff (ORCID: https://orcid.org/0000-0002-5003-508X)
- Rebecca D. Hodge (ORCID: https://orcid.org/0000-0002-5784-9668)
- Joseph T. Mahoney (ORCID: https://orcid.org/0000-0003-1374-3893)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Kyle J. Travaglini (ORCID: https://orcid.org/0000-0003-3164-6448)
- Mariano I. Gabitto (ORCID: https://orcid.org/0000-0001-6911-344X)
- Ed S. Lein (ORCID: https://orcid.org/0000-0001-9012-6552)
Institutions
- Allen Institute for Brain Science (US)
- University of Washington (US)
- Allen Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085234
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00