Revisiting the Wood Criteria for Frontotemporal Degeneration Pedigree Classification: 10 Years Later
These results reiterate the importance of gathering a detailed neurologic family history in genetic risk assessment for FTD. Given the emergence of gene-specific clinical trials, we suggest that using this cross-validated pedigree classification criteria provides an accurate first step in determining the likelihood of a genetic diagnosis. Genetic counseling and comprehensive testing should be routinely offered in clinical care for all patients with FTD, regardless of risk stratification.
Authors
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Vivianna M. Van Deerlin (ORCID: https://orcid.org/0000-0002-7400-9097)
- Sara Manning Peskin
- EunRan Suh
- Lauren Massimo (ORCID: https://orcid.org/0000-0002-3407-7335)
- Laynie Dratch (ORCID: https://orcid.org/0000-0002-2179-3199)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Julia Kwiecinski
- Allyson Hinks
Institutions
- Penn Center for AIDS Research (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087652
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00