Epigenetic age acceleration and cognitive resilience in the Framingham Heart Study
Epigenetic age acceleration may be a marker of cognitive resilience, particularly in executive function. Of the three epigenetic clocks examined, DundedinPACE showed the most robust associations with cognitive resilience, with lower DunedinPACE associated with greater cognitive resilience.
Authors
- Phillip H Hwang (ORCID: https://orcid.org/0000-0001-6780-6808)
- Daniel L. Levy (ORCID: https://orcid.org/0000-0002-7853-3275)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Michael L. Lee (ORCID: https://orcid.org/0000-0002-3112-1214)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Jiantao Ma (ORCID: https://orcid.org/0000-0001-7478-7203)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Ting Fang Alvin Ang (ORCID: https://orcid.org/0000-0003-4687-2552)
- Ashita S. Gurnani
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Laura E. Gibbons (ORCID: https://orcid.org/0000-0001-5054-2543)
- Sherral Devine (ORCID: https://orcid.org/0000-0002-5063-6651)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Ralph G. Dacey (ORCID: https://orcid.org/0000-0002-9181-6413)
- Phoebe Scollard
- Shruti Durape
- Richard Sherva (ORCID: https://orcid.org/0000-0003-2133-1493)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Chunyu Liu (ORCID: https://orcid.org/0000-0002-9160-0153)
- Yi Li (ORCID: https://orcid.org/0000-0002-3875-3513)
- Mengyao Wang (ORCID: https://orcid.org/0000-0002-4064-5538)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
Institutions
- Boston University (US)
- Tufts University (US)
- National Institutes of Health (US)
- University of Miami (US)
- University of Puget Sound (US)
- University of Washington (US)
- National Heart, Lung, and Blood Institute (US)
- Geriatric Research Education and Clinical Center (US)
- Framingham Heart Study (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091707
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00