Sex differences in the response to high pulse pressure in APOE4 mice
Our data indicate that high PP is detrimental to cerebral artery endothelial function in female, but not male, APOE4/hAβ mice. Additionally, female APOE4/hAβ mice have stiffer cerebral arteries and poorer spatial memory than male APOE4/hAβ mice. Our findings suggest that sex may influence the interactive effect of APOE4 and PP on cerebrovascular and AD-related outcomes.
Authors
- Scott Ferguson (ORCID: https://orcid.org/0000-0001-7937-8273)
- Ashley E. Walker (ORCID: https://orcid.org/0000-0003-1612-4545)
- Lazar N Isakharov
Institutions
- University of Oregon (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091925
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00