Localized Proteomics of Amyloid Plaque Tissue in Down Syndrome and Alzheimer’s Disease
We identified proteome differences in Aβ plaques across AD subtypes. Correlation and functional analyses revealed that DS and LOAD plaque-associated proteins primarily participate in lysosomal pathways, while EOAD proteins are linked to immune response. In contrast, EOAD and LOAD non-plaque proteins correlated better compared to DS, with functional differences reflected in the top GO terms.
Authors
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Alberto Lleó (ORCID: https://orcid.org/0000-0002-2568-5478)
- Dominique Leitner (ORCID: https://orcid.org/0000-0002-1371-9861)
- Beatrix Ueberheide (ORCID: https://orcid.org/0000-0003-2512-0204)
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Evgeny Kanshin (ORCID: https://orcid.org/0000-0001-7142-4554)
- Mitchell Marta Ariza
- Ana Giusti Pedrosa
- Jianina Suazo
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088962
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00