Examining pathology of Alzheimer’s disease via clusterin and Aβ interaction

This study highlighted the inhibition effect of Aβ by clusterin through its close interactions. Especially, specific fragments (#2) of clusterin strongly decreased Aβ oligomerization, and recovered cell viability after Aβ protofibril treatment. This suggested that clusterin supported the direct interaction with Aβ, furthermore involving its removal. In clinical aspects, the decreased levels of clusterin in AD plasma were observed, along with reduced clusterin-Aβ co-interactions, which indicated the potential impairments in Aβ clearance mechanisms, contributing to AD pathology progression. The findings contributed to our understanding of the complex interplays between Clusterin and Aβ in AD, offering insights for therapeutic and diagnostic development.