Cross‐Ancestry Meta‐Analysis of <i>APOE‐ε4</i> Stratified GWAS of Longitudinal Cognitive Decline in Older Adults
Our study has shed light on several novel genetic factors that relate to late-life cognitive performance in an APOE-specific manner. These findings enrich our understanding of the genetic landscape influencing cognitive decline. Further research is imperative to unravel how these genetic variations affect biological processes and the potential in guiding therapeutic strategies.
Authors
- Alex G. Contreras
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Weixin Wang (ORCID: https://orcid.org/0000-0002-2765-2629)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Michael L. Lee (ORCID: https://orcid.org/0000-0002-3112-1214)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Jaclyn M. Eissman (ORCID: https://orcid.org/0000-0001-6439-3999)
- Luigi Ferrucci (ORCID: https://orcid.org/0000-0002-6273-1613)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Skylar Walters
- Angela Lee Jefferson (ORCID: https://orcid.org/0000-0002-8245-0587)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Phoebe Scollard
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Brian W. Kunkle (ORCID: https://orcid.org/0000-0002-9515-5157)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Gerard D. Schellenberg (ORCID: https://orcid.org/0000-0003-1115-2475)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Alaina Durant
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Amanda Kuzma
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Sterling C. Johnson
- Marilyn S. Albert
- Jonathan L. Haines
- Margaret A Pericak‐Vance
- Alexandra N. Regelson
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Miami (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- VA Puget Sound Health Care System (US)
- Dr. John T. Macdonald Foundation (US)
- National Institute on Aging (US)
- Rush University (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090846
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00