Shared transcriptomic similarities between mouse and <i>C. elegans</i> transgenic models of Alzheimer’s disease
Our results indicate significant overlaps in genes and biological processes associated with AD and neurodegeneration between AD nematode and mice models, highlighting the translational conservation of fundamental pathological mechanisms. The differences in expression and processes between the various strains of C. elegans and the mouse models offer a unique window to investigate specific molecular aspects of AD.
Authors
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Giovanna Carello‐Collar (ORCID: https://orcid.org/0000-0003-4644-0151)
- Karine Rigon Zimmer (ORCID: https://orcid.org/0000-0002-7962-7353)
- Marco De Bastiani (ORCID: https://orcid.org/0000-0002-6212-1858)
- Flávia Suelen de Oliveira Pereira (ORCID: https://orcid.org/0000-0002-0286-1424)
- Vitória Vitalina Margarita Ryssina
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Universidade Federal do Pampa (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092954
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00