Prostaglandin D2 synthase is differentially methylated specifically in Huntington’s Disease
This study validates our previous findings of PTGDS hypomethylation in HD in the striatum and presents novel associations at the EC. Together, these findings suggest further investigation of PTGDS, given others report differential expression in HD oligodendrocytes. Future studies should address the cell-specific profile of PTGDS methylation and its transcriptional regulation in HD through fluorescent activated cell sorting.
Authors
- Safa Al‐Sarraj (ORCID: https://orcid.org/0000-0002-6783-3571)
- Rebecca G. Smith (ORCID: https://orcid.org/0000-0001-9264-1056)
- Claire Troakes (ORCID: https://orcid.org/0000-0002-1790-7376)
- Greg Wheildon (ORCID: https://orcid.org/0000-0002-7911-9973)
- Luke Weymouth (ORCID: https://orcid.org/0000-0002-1168-6015)
- Katie Lunnon (ORCID: https://orcid.org/0000-0001-7570-6065)
- Adam R. Smith (ORCID: https://orcid.org/0000-0001-6495-2711)
Institutions
- King's College London (GB)
- University of Exeter (GB)
- King's College Hospital NHS Foundation Trust (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084097
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council