Cell‐type specific contribution to sex differences in Alzheimer’s Disease revealed using single‐cell transcriptomes
We identified dozens of novel sex-specific molecular associations and interesting cell-cell communication pattern differences between sexes. Future mechanistic studies should connect these genes with their downstream effectors in a cell-type specific manner.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Yiyang Wu (ORCID: https://orcid.org/0000-0002-9231-7093)
Institutions
- Rush University Medical Center (US)
- Columbia University Irving Medical Center (US)
- Rush University (US)
- Columbia University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092518
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00