Interactions with regulatory antibodies modulate CHIP E3 ubiquitin ligase‐driven tau clearance
Functional screening of Fabs that were generated to specifically target 3D epitopes on CHIP have revealed potent modes of CHIP functional modulation. Insights from the corresponding CHIP-Fab complex structures help in better understanding the CHIP-driven tau clearance mechanisms and in describing unique therapeutic target sites on CHIP.
Authors
- Emily J. Connelly (ORCID: https://orcid.org/0000-0003-0732-1627)
- Aparna Unnikrishnan (ORCID: https://orcid.org/0000-0002-6668-8659)
- Dong hee Chung
- Aye C. Thwin (ORCID: https://orcid.org/0000-0002-1423-8189)
- Daniel R. Southworth (ORCID: https://orcid.org/0000-0001-7108-9389)
- Charles S. Craik (ORCID: https://orcid.org/0000-0001-7704-9185)
- Cory M. Nadel (ORCID: https://orcid.org/0000-0001-6827-3302)
Institutions
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086539
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00