Subtype‐specific patterns of tau pathology in Alzheimer’s and related disorders
Results elucidate distinct tau deposition patterns in AD, PCA, and lvPPA, providing insights into subtype-specific pathophysiology. The correlation matrix and GLMs highlight the significance of evolutionary expansion and cerebrovascular health in tau accumulation. Associations underscore the complex interplay of gene expression, myelin mapping, and cortical thickness with tau pathology. Findings contribute to understanding heterogeneity within AD spectrum disorders, emphasizing the multifaceted nature of neurodegenerative processes. Further research promises refined diagnostic and therapeutic strategies tailored to distinct neurobiological profiles in AD, PCA, and lvPPA.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Aristeidis Sotiras (ORCID: https://orcid.org/0000-0003-0795-8820)
- Peter R Millar (ORCID: https://orcid.org/0000-0003-4588-739X)
- Austin McCullough (ORCID: https://orcid.org/0000-0001-9192-111X)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Sarah Keefe (ORCID: https://orcid.org/0000-0002-5943-0940)
- Diana A. Hobbs (ORCID: https://orcid.org/0000-0001-7822-6411)
- Shaney Flores (ORCID: https://orcid.org/0000-0003-2726-8704)
- Stephanie Doering (ORCID: https://orcid.org/0000-0001-5110-0640)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
Institutions
- Washington University in St. Louis (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086138
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00