Molecular Characterization of Knock‐In Mouse Models Harboring Genetic Risk Factors for Late‐Onset Alzheimer’s Disease

We have characterized in vivo signatures of nine genetic candidates for LOAD, identifying alterations in specific LOAD-related pathways in each variant on a sensitized genetic background. These results provide animal models for preclinical testing of therapeutics designed to correct specific molecular alterations that contribute to LOAD pathology and progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.086533
Primary Topic
Bioinformatics and Genomic Networks
Type
article
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article

Molecular Characterization of Knock‐In Mouse Models Harboring Genetic Risk Factors for Late‐Onset Alzheimer’s Disease

Gregory W. Carter
Alzheimer s & Dementia
Bioinformatics and Genomic Networks
article

Molecular Characterization of Knock‐In Mouse Models Harboring Genetic Risk Factors for Late‐Onset Alzheimer’s Disease

Gregory W. Carter
article en

Abstract

We have characterized in vivo signatures of nine genetic candidates for LOAD, identifying alterations in specific LOAD-related pathways in each variant on a sensitized genetic background. These results provide animal models for preclinical testing of therapeutics designed to correct specific molecular alterations that contribute to LOAD pathology and progression.

Alzheimer s & DementiaVol. 20(S1)
Jackson Laboratory (US)
Openalex Percentile: Top 78%
Bioinformatics and Genomic Networks
DOIOpen Access PDFOpenAlex
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Molecular Characterization of Knock‐In Mouse Models Harboring Genetic Risk Factors for Late‐Onset Alzheimer’s Disease — Gregory W. Carter · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS