AD risk alleles elevate microglial cGAS‐associated senescence and neurodegeneration in tauopathy
Taken together, cGAS-STING and senescence pathways are known drivers of neurodegeneration, and our study further links upregulation of these pathways to the strongest AD risk factors. This evidence points to cGAS-STING and senescence as vital pathological mechanisms in AD and important targets for future therapeutics.
Authors
- Sarah Naguib
- Li Gan
Institutions
- Cornell University (US)
- MIND Research Institute (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084590
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00