Causal network analysis on multi‐omics data from Alzheimer’s brain reveals strong connection between mitochondria functions and AD outcomes
Clustering analysis based on in silico causal relationships of clinical and multi-omic data revealed a strong connection of genes involved in mitochondria functions with cognition and AD pathology, reminiscing "mitochondria cascade hypothesis" of AD first proposed two decades ago.
Authors
- Jeanne C. Latourelle (ORCID: https://orcid.org/0000-0002-4218-9572)
- Ole Isacson (ORCID: https://orcid.org/0000-0001-8091-8302)
- Apoorva Bharthur Sanjay (ORCID: https://orcid.org/0000-0001-9082-0587)
- Li Sun
- So‐Youn Shin
Institutions
- Harvard University (US)
- McLean Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085208
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00