Single Nucleus RNA Sequencing Reveals Interaction Between Microglia and Endothelial Cells in Mixed Alzheimer’s Disease and Vascular Pathology
We identified genes that are differentially expressed in endothelial cells and microglia in hippocampus from persons with AD+VaD compared to other AD diagnoses. These patterns suggest that AD+VaD cases have reduced microglial activation and increased angiogenesis in the brain.
Authors
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-8237-1857)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Melissa Wong (ORCID: https://orcid.org/0000-0003-2549-9621)
- Oluwatosin A Olayinka
- Benjamin L. Wolozin (ORCID: https://orcid.org/0000-0003-2068-1475)
- Nicholas K. O’Neill (ORCID: https://orcid.org/0000-0002-9953-9940)
- Jenny A Empawi
- Junming Hu (ORCID: https://orcid.org/0000-0002-6503-7491)
- Payton Bock
Institutions
- Boston University (US)
- VA Boston Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089628
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.49