Using proximity labelling to investigate astrocytic protein profile changes in response to amyloid pathology in a mammalian model of Alzheimer’s disease

This work enables a better understanding of astrocyte-specific membrane and extracellular protein changes as the disease progresses in a mammalian model of AD. An enhanced understanding of this will not only provide insight into astrocyte biology more generally, but may ultimately be vital for identification of novel biomarkers and therapeutic targets for detecting and treating AD.