The crosstalk between insulin resistance and tau pathology

The study provides evidence supporting insulin resistance as a contributing risk factor for tau pathology development, potentially leading to Alzheimer's disease later in life. Tau aggregates may increase the likelihood of insulin resistance by impairing the insulin signaling pathway, ultimately resulting in Type 2 diabetes. The findings suggest that impaired insulin signaling in the brain could contribute to tau pathogenesis by decreasing GLUT4 expression, leading to hyperglycemia and cellular hypertrophy.