Unraveling Vascular and Parenchymal Microenvironment Changes in Patients with Mixed CAA/AD Pathology: A Spatial Transcriptomic In‐Depth Analysis
In summary, the identified differential (parenchymal vs vascular) genes underscore a clear association with alterations in the neurovascular microenvironment, indicating a discernible shift in vasculature dynamics attributed to amyloid presence. This observation emphasizes the significance of comprehending the changes within the vascular unit to address Cerebral Amyloid Angiopathy (CAA) thoroughly to develop comprehensive strategies to tackle CAA-related challenges.
Authors
- Javier Redding‐Ochoa (ORCID: https://orcid.org/0000-0002-0677-917X)
- Nur Jury Garfe
- Cristian A Lasagna Reeves
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Travis S. Johnson (ORCID: https://orcid.org/0000-0002-4628-2256)
- Eduardo Juárez (ORCID: https://orcid.org/0000-0002-6096-1511)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Indiana Biosciences Research Institute (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087677
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00