Whole genome methylation sequencing identifies sex‐specific DNA methylation levels in late onset dementia due to Alzheimer’s disease
33,732 unique, sex-specific DMPs in AD were identified with more than 60% annotated to one of 5,067 genes. DMP-associated genes have sex-specific DNA methylation levels suggesting that these DMPs may play a role in the biased pathogenesis of AD.
Authors
- Andy Madrid (ORCID: https://orcid.org/0000-0001-8612-5995)
- Sündüz Keleş (ORCID: https://orcid.org/0000-0001-9048-0922)
- Reid S. Alisch (ORCID: https://orcid.org/0000-0003-0637-4137)
- Kirk J. Hogan (ORCID: https://orcid.org/0000-0001-6329-2651)
- Ligia A. Papale (ORCID: https://orcid.org/0000-0002-6457-0358)
- Coleman Breen (ORCID: https://orcid.org/0000-0003-1227-7712)
- Lindsay R. Clark (ORCID: https://orcid.org/0000-0003-4837-7627)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Sterling C. Johnson
- Phillip E. Bergmann (ORCID: https://orcid.org/0000-0002-1049-8661)
Institutions
- University of Wisconsin–Madison (US)
- Geriatric Research Education and Clinical Center (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087422
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00