Omics analysis of Alzheimer’s disease stratified by the microglial polygenic effect
The stratification analysis of AD by PRS suggests that microglial reactivity differs among AD patient groups. Future detailed microglial observations in postmortem brains from AD patients with low PRS and those with high PRS will further elaborate our results.
Authors
- Norikazu Hara (ORCID: https://orcid.org/0000-0001-8525-3469)
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Shigeo Murayama (ORCID: https://orcid.org/0000-0001-9709-5242)
- Michiko Sekiya (ORCID: https://orcid.org/0000-0001-8275-8293)
- M. Hasegawa (ORCID: https://orcid.org/0000-0001-9234-6014)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Yu Hirota (ORCID: https://orcid.org/0000-0002-7107-2197)
- Yasufumi Sakakibara (ORCID: https://orcid.org/0000-0002-7459-1611)
- Akinori Miyashita (ORCID: https://orcid.org/0000-0003-2508-9649)
- Yuko Saito (ORCID: https://orcid.org/0000-0003-4112-2584)
- Koichi Iijima (ORCID: https://orcid.org/0000-0003-4794-1863)
Institutions
- Tokyo Metropolitan Geriatric Hospital (JP)
- National Center for Geriatrics and Gerontology (JP)
- Niigata University (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088489
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00