Associations between AD polygenic risk scores and global amyloid deposition in the European AMYPAD consortium
We highlight the significant influence of APOE in determining AD genetic predisposition, and that AD PRS are associated with amyloid deposition. Our results show that AMYPAD is a suitable cohort for studying genetic factors driving amyloid deposition before clinical onset, which we aim to extend with the inclusion of more parent cohorts, and regional and longitudinal amyloid data.
Authors
- Emma S. Luckett (ORCID: https://orcid.org/0000-0003-1777-4742)
- David Vállez García (ORCID: https://orcid.org/0000-0003-3308-3167)
- Isadora Lopes Alves (ORCID: https://orcid.org/0000-0002-1230-8139)
- Luigi Lorenzini (ORCID: https://orcid.org/0000-0002-9756-881X)
- Pieter Jelle Visser (ORCID: https://orcid.org/0000-0001-8008-9727)
- Craig Ritchie (ORCID: https://orcid.org/0000-0002-6202-6906)
- Anouk den Braber (ORCID: https://orcid.org/0000-0002-3377-2627)
- Yasmina Abakkouy (ORCID: https://orcid.org/0000-0002-6601-4048)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Gill Farrar (ORCID: https://orcid.org/0000-0002-0726-723X)
- Natàlia Vilor‐Tejedor (ORCID: https://orcid.org/0000-0003-4935-6721)
- Isabelle Cleynen (ORCID: https://orcid.org/0000-0003-0857-7683)
- Mahnaz Shekari (ORCID: https://orcid.org/0000-0003-0531-8651)
- Robin Wolz
- Lyduine E. Collij
Institutions
- Netherlands Institute for Neuroscience (NL)
- Universitat Pompeu Fabra (ES)
- Lund University (SE)
- Erasmus MC (NL)
- Karolinska Institutet (SE)
- Ixico (United Kingdom) (GB)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- Amsterdam Neuroscience (NL)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- Centre for Genomic Regulation (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Hospital del Mar Research Institute (ES)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088788
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00