Pathway‐specific polygenic risk score analysis to explore the inverse association between cancer and Alzheimer’s disease neuropathologic changes
While selection and survival bias cannot be completely ruled out, disruptions of specific biological pathways may contribute to the observed inverse relationship of cancer and AD. Further research may clarify the underlying mechanisms between AD and cancer inverse relationship by incorporating with cancer PRS.
Authors
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Yuriko Katsumata (ORCID: https://orcid.org/0000-0002-0188-8094)
- Shama D. Karanth (ORCID: https://orcid.org/0000-0001-5371-6908)
- Erin L. Abner (ORCID: https://orcid.org/0000-0002-9566-4111)
- Khine Zin Aung (ORCID: https://orcid.org/0009-0000-3793-6927)
- David W. Fardo (ORCID: https://orcid.org/0000-0002-7207-4696)
- Xian Wu (ORCID: https://orcid.org/0000-0003-1118-9710)
Institutions
- University of Kentucky (US)
- University of Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089559
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00