The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
We report associations between the NLR and Aβ42 in the older ADNI cohort, and between the NLR and t-tau and p-tau<sub>181</sub> in the younger NYU cohort. Associations persisted after adjusting for comorbidities, suggesting a direct link between the NLR and AD. However, changes in associations between the NLR and specific AD-biomarkers may occur as part of immunosenescence.
Authors
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Sean Jacobson (ORCID: https://orcid.org/0000-0001-9937-419X)
- Rebecca A. Betensky (ORCID: https://orcid.org/0000-0002-3793-1437)
- Luisa F Figueredo (ORCID: https://orcid.org/0000-0001-6401-555X)
- Henry Rusinek (ORCID: https://orcid.org/0000-0001-6035-6314)
- Lidia Glodzik (ORCID: https://orcid.org/0000-0003-4934-0949)
- Ricardo S. Osorio (ORCID: https://orcid.org/0000-0002-2735-9609)
- Jaime Ramos‐Cejudo (ORCID: https://orcid.org/0000-0002-0993-9909)
- Alok Vedvyas
- Esther Blessing (ORCID: https://orcid.org/0000-0002-7961-8844)
- Chelsea Reichert Plaska (ORCID: https://orcid.org/0000-0001-9662-6179)
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Karyn Marsh (ORCID: https://orcid.org/0009-0003-9057-1551)
- Jeffrey S. Berger (ORCID: https://orcid.org/0000-0001-8216-4647)
- Mony J. de Leon (ORCID: https://orcid.org/0000-0003-4741-406X)
- Tovia Jacobs
- Moses Gonzalez
Institutions
- University of Southern California (US)
- Universitat Autònoma de Barcelona (ES)
- Cornell University (US)
- Hospital de Sant Pau (ES)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092957
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00