Sexual dimorphic synaptic dysfunction and cognition in a mouse model of Alzheimer’s disease
Our findings confirm a sex-dependent hyper-to-hypoactivation glutamatergic paradigm in APP<sup>NL-F</sup> mice. Additionally, we observed a sexually dimorphic biological aging process resulting in a more severe cognitive phenotype for female APP<sup>NL-F</sup> mice than males. This research mirrors that of human AD pathology and provides further evidence of divergent AD pathogenesis between sexes.
Authors
- Kevin N. Hascup (ORCID: https://orcid.org/0000-0001-6604-1874)
- Kathleen Quinn
- Samuel McFadden (ORCID: https://orcid.org/0000-0002-2289-5066)
- Erin R. Hascup (ORCID: https://orcid.org/0000-0003-1037-0809)
- Mackenzie R. Peck
- Caleigh A. Findley (ORCID: https://orcid.org/0000-0002-8759-1661)
- Tiarra Hill
Institutions
- Southern Illinois University School of Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090760
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00