The pTau217 interactome in human Alzheimer’s disease brain tissue from APOE3 and APOE4 carriers
pTau217 interacts with many similar proteins to pTauS396/S404. Our results highlight a strong interaction between multiple pTau species and a novel E3 ubiquitin ligase, which may have an important role in AD and potentially tau degradation.
Authors
- Tomas Kavanagh (ORCID: https://orcid.org/0000-0003-2184-3552)
- Jackeline Ponce (ORCID: https://orcid.org/0000-0002-3886-9989)
- Beatrix Ueberheide (ORCID: https://orcid.org/0000-0003-2512-0204)
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Eleanor Drummond (ORCID: https://orcid.org/0000-0002-5466-4609)
- Manon Thierry
Institutions
- The University of Sydney (AU)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090560
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00