Unravelling neurodegenerative effects of SARS‐CoV‐2 infection in Alzheimer’s disease‐ brain organoids
Our research reveals a heightened susceptibility of Alzheimer's disease-derived brain organoids to SARS-CoV-2 infection together with a notable accumulation of Aβ peptides. These findings suggest a potential link between viral exposure and exacerbation of neurodegenerative markers in Alzheimer's disease, underscoring the urgent need for further exploration of this relationship amid the evolving landscape of the COVID-19 pandemic.
Authors
- Ángel Gil
- Sandra Acosta (ORCID: https://orcid.org/0000-0001-6582-2572)
- Maria Carmen Puertas (ORCID: https://orcid.org/0000-0002-6750-2318)
- Arcadi Navarro (ORCID: https://orcid.org/0000-0003-2162-8246)
- Javier Martinez Picado
- Peter F. Infante (ORCID: https://orcid.org/0000-0001-5350-0154)
- Isabel Turpin
- Andrea Martí Sarrias
- Laura García González (ORCID: https://orcid.org/0000-0002-3815-158X)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- IrsiCaixa (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Institut de Biologia Evolutiva (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Centre for Genomic Regulation (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092158
- Citations
- 1
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.37