Lewy body pathology in autosomal dominant and sporadic Alzheimer’s disease – neuropathological distribution patterns and associated survival and genetic findings
Distribution of LBP is focal in two-thirds of ADAD with LBP and a little less than half of sAD patients with LBP. The longer survival in ADAD and sAD patients with focal but not widespread LBP may suggest that spreading of LBP in AD does not follow the same spatial evolution as described by Braak stages, but exhibits a unique, AD-specific pattern. The association of APOE4 positivity with both focal and widespread LBP in AD and of PD-PRS with widespread LBP in sAD indicates a genetic component that influences occurrence and distribution of LBP in AD.
Authors
- Thomas Arzberger
- Mathias Jucker (ORCID: https://orcid.org/0000-0001-9045-1072)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Erin Franklin (ORCID: https://orcid.org/0000-0002-6614-4109)
- Jonathan Vöglein (ORCID: https://orcid.org/0000-0002-5965-838X)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Tammaryn Lashley (ORCID: https://orcid.org/0000-0001-7389-0348)
- Chengjie Xiong (ORCID: https://orcid.org/0000-0003-0044-4499)
- John C. Morris (ORCID: https://orcid.org/0000-0001-9820-5618)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Jochen Herms (ORCID: https://orcid.org/0000-0002-6201-1042)
- Priyanka Gorijala (ORCID: https://orcid.org/0000-0001-7109-7362)
- Adrian Danek (ORCID: https://orcid.org/0000-0001-8857-5383)
- Katrina L. Paumier (ORCID: https://orcid.org/0000-0003-2455-5222)
- Natalie S. Ryan (ORCID: https://orcid.org/0000-0003-0361-7455)
- Nigel J. Cairns
Institutions
- Washington University in St. Louis (US)
- University of Exeter (GB)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088905
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.23