Molecular Mechanism of Substrate Recognition and Cleavage by Human γ‐Secretase

Therefore, each cleavage is followed by unwinding of the substrate α-helix by one turn, translocation of the α-helix towards the C-terminus, and formation of a new β-strand. This mechanism is consistent with existing biochemical data and may also explain the cleavages of other substrates by human γ-secretase.

Authors

Xuefei Guo (ORCID: https://orcid.org/0000-0001-7135-0954)

Institutions

Tsinghua University (CN)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2024-12-01
DOI: https://doi.org/10.1002/alz.092188
Primary Topic: RNA Interference and Gene Delivery
Type: article
Field-Weighted Citation Impact: 0.00

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article

Molecular Mechanism of Substrate Recognition and Cleavage by Human γ‐Secretase

Xuefei Guo

Dec 1, 2024

Alzheimer s & Dementia

RNA Interference and Gene Delivery

article

Molecular Mechanism of Substrate Recognition and Cleavage by Human γ‐Secretase

Xuefei Guo

December 1, 2024article en

Abstract

Alzheimer s & DementiaVol. 20(S1)

Tsinghua University (CN)

Openalex Percentile: Top 78%

RNA Interference and Gene Delivery

DOI Open Access PDF OpenAlex

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Molecular Mechanism of Substrate Recognition and Cleavage by Human γ‐Secretase — Xuefei Guo · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS