Increasing cerebral blood flow reduces neural activity derangement in mouse models of Alzheimer’s disease
Our data suggests some aspects of the neural and behavioral deficits in AD are acutely recoverable by increasing CBF. Such recovery demonstrates a promising avenue for future therapeutic targets to combat the symptoms of AD in humans.
Authors
- Matthew Isaacson (ORCID: https://orcid.org/0000-0001-8797-0090)
- Nozomi Nishimura (ORCID: https://orcid.org/0000-0003-4342-9416)
- Chris B. Schaffer (ORCID: https://orcid.org/0000-0002-7800-9596)
- Michael R. E. Lamont (ORCID: https://orcid.org/0000-0002-2933-0842)
- Rick Zirkel (ORCID: https://orcid.org/0000-0003-1744-0785)
Institutions
- Cornell University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086922
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00