Sex‐associated differences in brain insulin signaling and energy metabolism uncover early pathological alterations driving Alzheimer’s disease neuropathology
This study highlights the importance of identifying sex-related differences as well as shared features in the progression of bIR in AD. Loss of BVR-A is a common event, although temporal- and regional-associated differences in males and females are observed. These observations warrant further investigations to unveil early pathological changes driving AD neuropathology.
Authors
- Bindu D. Paul (ORCID: https://orcid.org/0000-0002-1862-6103)
- Eugenio Barone (ORCID: https://orcid.org/0000-0002-7028-4251)
- Simona Lanzillotta (ORCID: https://orcid.org/0000-0001-8421-023X)
- Fabio Di Domenico (ORCID: https://orcid.org/0000-0002-2013-209X)
- Marzia Perluigi (ORCID: https://orcid.org/0000-0003-4668-5239)
- Antonella Tramutola (ORCID: https://orcid.org/0000-0002-9564-2086)
Institutions
- Johns Hopkins University (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085410
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00