Comparing methods of cellular segmentation in prefrontal and primary visual cortices in Alzheimer’s disease
Comparisons between the image analysis modalities demonstrate that the method by which cells are segmented and classified can impact the interpretation of MxIF data. Combining knowledge of disease biology with a deeper understanding of when and how to use these techniques will improve data precision.
Authors
- Daniel Meyer (ORCID: https://orcid.org/0000-0003-4720-9891)
- S. Antonio Abate
- Elizabeth McDonough (ORCID: https://orcid.org/0000-0002-4087-2546)
- Lisa Lowery
- Merina Varghese (ORCID: https://orcid.org/0000-0002-1517-3903)
- Patrick R. Hof (ORCID: https://orcid.org/0000-0002-3208-1154)
- Jennifer I. Luebke (ORCID: https://orcid.org/0000-0003-1399-6073)
- Alec K McKendell
Institutions
- Boston University (US)
- GE Global Research (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093006
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00