Longitudinal association between CSF markers of Alzheimer Disease and inflammation in preclinical Alzheimer Disease

These investigations of CSF proteins in preclinical AD persons identified inflammatory markers that exhibited specific relationships with p(181)tau and Aβ42 across time and sex. These results may guide further study of biomarkers for detection of AD in its preclinical stages, and/or therapeutic strategies. Of special importance, characterization of the pathogenesis of pre-symptomatic AD may facilitate development of early interventions for the prevention of AD dementia.