House dust mite‐induced asthma alters BBB integrity, increases amyloid beta accumulation, and alters brain cytokine levels in <i>App<sup>NL‐G‐F</sup></i> mice
Dust-mite exposure induced a severe asthma-like condition that exacerbated Aβ pathology, astrogliosis, cytokine changes, and disturbed BBB integrity in the brains of male and female App<sup>NL-G-F</sup> mice. Defining the mechanisms of secondary effects of asthma on the brain may provide a novel therapeutic approach for both asthma and AD.
Authors
- Nilesh Sudhakar Ambhore (ORCID: https://orcid.org/0000-0002-9293-6062)
- Venkatachalem Sathish (ORCID: https://orcid.org/0000-0001-9770-8299)
- Angela M. Floden
- Suba Nookala (ORCID: https://orcid.org/0000-0002-4632-265X)
- Bijayani Sahu (ORCID: https://orcid.org/0000-0002-3473-4024)
- Colin K. Combs (ORCID: https://orcid.org/0000-0001-8671-5880)
Institutions
- University of North Dakota (US)
- North Dakota State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091066
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00