Differential effects of <i>Apoe Christchurch (R136S)</i> mutation on amyloid plaque and tau pathology in transgenic mouse models
ApoeCh mutation has differential effects on glial responses to plaque and tau. ApoeCh decreases plaque load and plasma NfL but increases inflammatory response to plaques. Whereas in a tau model, ApoeCh increases phosphorylated tau level but decreases microgliosis and inflammatory response to tau pathology.
Authors
- Nellie Kwang (ORCID: https://orcid.org/0000-0001-8890-4976)
- Frank M. LaFerla (ORCID: https://orcid.org/0000-0003-2324-6911)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Kristine M. Tran (ORCID: https://orcid.org/0000-0002-4444-7221)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Celia Da Cunha
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Kim N. Green
- Cassandra Mar
- Donna Chao
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091903
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00