Enrichment of somatic cancer driver mutations in Alzheimer’s disease microglia and its association with neuroinflammation
Our findings indicate that proliferation-related somatic mutations in microglia are prevalent in normal aging but further enriched in AD, driving MiCE and promoting inflammatory, disease-related microglial signatures. This study provides crucial insights into microglial clonal dynamics in AD, potentially paving the way for novel approaches to AD diagnosis and therapy.
Authors
- Michael B. Miller (ORCID: https://orcid.org/0000-0002-6205-3314)
- Edward Stronge
- Maya Talukdar (ORCID: https://orcid.org/0000-0002-5997-5633)
- Christopher A. Walsh (ORCID: https://orcid.org/0000-0002-0156-2238)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Rebecca D. Hodge (ORCID: https://orcid.org/0000-0002-5784-9668)
- Brian H. Chhouk
- Jaejoon Choi (ORCID: https://orcid.org/0000-0002-6695-2157)
- Kyle J. Travaglini (ORCID: https://orcid.org/0000-0003-3164-6448)
- Dachan Kim (ORCID: https://orcid.org/0000-0001-5196-8482)
- August Yue Huang (ORCID: https://orcid.org/0000-0002-0416-2854)
- Mariano I. Gabitto (ORCID: https://orcid.org/0000-0001-6911-344X)
- Eunjung Alice Lee (ORCID: https://orcid.org/0000-0002-6574-9261)
- Junho Kim (ORCID: https://orcid.org/0000-0003-3513-401X)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Sattar Khoshkhoo (ORCID: https://orcid.org/0000-0003-3348-557X)
- Liz Enyenihi (ORCID: https://orcid.org/0000-0001-6952-1515)
- Javier Ganz (ORCID: https://orcid.org/0000-0002-2370-9819)
- Zinan Zhou (ORCID: https://orcid.org/0000-0003-2014-3650)
- Ed S. Lein (ORCID: https://orcid.org/0000-0001-9012-6552)
- Boxun Zhao (ORCID: https://orcid.org/0000-0003-2337-5756)
- Eitan S Kaplan (ORCID: https://orcid.org/0000-0002-9355-324X)
- Ila Rosen
Institutions
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Boston Children's Hospital (US)
- Allen Institute for Brain Science (US)
- Harvard University (US)
- Columbia University Irving Medical Center (US)
- Allen Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084786
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00