Pathways of inhibitory interneuron dysregulation in 5XFAD mice
The most significant altered pathways within AD interneurons at the earliest stages of disease included neurodegeneration and metabolism pathways. Zero or few DEGs overlapped across all regions or neuronal subtypes. Thus, interneurons display distinct profiles and transcriptional changes by brain area at early- and late-stage disease. These findings will inform future mechanistic experimentation, and suggest investigation into neural circuit dysfunction in AD will require consideration of anatomic subregion specificity.
Authors
- Masha G. Savelieff (ORCID: https://orcid.org/0000-0001-5575-2494)
- Diana M Rigan (ORCID: https://orcid.org/0000-0003-4564-2130)
- John M. Hayes (ORCID: https://orcid.org/0000-0002-5677-2216)
- Mohamed H. Noureldein (ORCID: https://orcid.org/0000-0002-7021-1511)
- Eva L. Feldman (ORCID: https://orcid.org/0000-0002-9162-2694)
- Kevin S. Chen (ORCID: https://orcid.org/0000-0003-0738-3799)
Institutions
- University of North Dakota (US)
- University of Michigan (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086555
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00