Nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
Combined, our data document spontaneous numtogenesis in human cells and demonstrate an association between brain cortical somatic Numts and human lifespan. These findings open the possibility that mito-nuclear horizontal gene transfer among human post-mitotic tissues produces functionally-relevant human Numts over timescales shorter than previously assumed.
Authors
- Gabriel Sturm (ORCID: https://orcid.org/0000-0002-7280-4310)
- Ryan E. Mills (ORCID: https://orcid.org/0000-0003-3425-6998)
- Hans‐Ulrich Klein (ORCID: https://orcid.org/0000-0002-6382-9428)
- Martin Picard (ORCID: https://orcid.org/0000-0003-2835-0478)
- Weichen Zhou (ORCID: https://orcid.org/0000-0003-4755-1072)
- Kalpita R. Karan (ORCID: https://orcid.org/0000-0002-4152-7541)
- Philip L. De Jager
- Wenjin Gu
- David A. Bennett
- Michio Hirano (ORCID: https://orcid.org/0000-0002-7070-7402)
Institutions
- Rush University Medical Center (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085457
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00