Microglial and neuronal subpopulations associated with cognitive resilience to amyloid deposition in genetically diverse mice

This study suggests that cell-type specific transcriptomic response to amyloid is modulated by genetic background and our findings re-iterate the importance of incorporating genetic diversity to model phenotypic and molecular heterogeneity in AD. Since the nuclei enriched in this dataset are enriched for neurons, future interrogations will provide evidence for specific neuronal populations and molecular mechanisms that differentiate cognitively resilient PWK from susceptible B6 mice, providing insights into mechanisms that can be leveraged to promote AD resilience.