Aβ immunotherapy drives immune activation and cerebrovascular damage in a mouse model of Alzheimer’s Disease

In summary, our study establishes a significant link between CAA-Aβ antibody immune complex formation, macrophage activation, vascular damage leading to impairment of BBB integrity. Nevertheless, the full implications of this phenomenon on the susceptibility to microhemorrhages needs to be explored further. Therefore, additional investigations are needed to determine the potential preferential roles played by tissue-resident and monocyte-derived macrophages surrounding vascular amyloid deposits, unraveling the intricate interplay between immune activation, vascular damage and accelerated smooth muscle cell loss in response to Aβ immunotherapy.