Evaluating ambroxol as an agent to boost lysosomal function and reduce beta amyloid in 3xTg mice

Our findings demonstrate that ambroxol is able to reduce intracellular accumulation of Aβ by upregulating lysosomal activity, and therefore may be a promising treatment for AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.093495
Primary Topic
Neuroscience and Neuropharmacology Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Evaluating ambroxol as an agent to boost lysosomal function and reduce beta amyloid in 3xTg mice

Shyam Gajavelli, Adrianna R Tsang, Stephen Pasternak, Lynn Wang
Alzheimer s & Dementia
Neuroscience and Neuropharmacology Research
article

Evaluating ambroxol as an agent to boost lysosomal function and reduce beta amyloid in 3xTg mice

Shyam Gajavelli, Adrianna R Tsang, Stephen Pasternak, Lynn Wang
article en

Abstract

Our findings demonstrate that ambroxol is able to reduce intracellular accumulation of Aβ by upregulating lysosomal activity, and therefore may be a promising treatment for AD.

Alzheimer s & DementiaVol. 20(S1)
Western University (CA)
Openalex Percentile: Top 74%
Neuroscience and Neuropharmacology Research
DOIOpen Access PDFOpenAlex
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Evaluating ambroxol as an agent to boost lysosomal function and reduce beta amyloid in 3xTg mice — Shyam Gajavelli, Adrianna R Tsang, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS