Marmoset cognitive aging: Heterogeneity and synaptic dysfunction
We posit that failed scaling results in mismatched energy supply and demand, leading to impaired synaptic transmission. This novel mechanism of synapse dysfunction differentiates aged marmosets with cognitive impairment from those without. Together, this work demonstrates the importance of comprehensive cognitive phenotyping to uncover the neurobiological consequences of aging, and firmly establishes the common marmoset as an advantageous model for age-related cognitive impairment.
Authors
- Courtney Glavis‐Bloom (ORCID: https://orcid.org/0000-0001-5148-9780)
- Masaaki Kuwajima (ORCID: https://orcid.org/0000-0002-1478-3726)
- John H. Reynolds
- Sammy Weiser Novak (ORCID: https://orcid.org/0000-0002-8344-9772)
- Kristen M. Harris (ORCID: https://orcid.org/0000-0002-1943-4744)
- Casey R. Vanderlip (ORCID: https://orcid.org/0000-0002-8233-5829)
- Uri Manor (ORCID: https://orcid.org/0000-0002-9802-1955)
- Lyndsey M. Kirk (ORCID: https://orcid.org/0000-0002-5125-652X)
- Payton A Asch (ORCID: https://orcid.org/0009-0002-8465-4628)
Institutions
- Salk Institute for Biological Studies (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085459
- Primary Topic
- Primate Behavior and Ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00