Comprehensive Analysis of Genetic Contributions to Alzheimer’s Disease and Frontotemporal Dementia in Admixed Latin American Populations

Our findings represent a pivotal step in understanding the genetic landscape of AD and FTD in admixed populations. They underscore the importance of including diverse populations in genetic research, paving the way for future studies. These findings have the potential to inform more personalized approaches to the diagnosis and treatment of neurodegenerative diseases in diverse global populations, as well as identify novel targets for therapeutic development.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.093055
Primary Topic
Biological Research and Disease Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Comprehensive Analysis of Genetic Contributions to Alzheimer’s Disease and Frontotemporal Dementia in Admixed Latin American Populations

Nilton Custodio, Teresita Ramos Franco, Stefanie Danielle Piña‐Escudero, Leonel Tadao Takada et al.
Alzheimer s & Dementia
Biological Research and Disease Studies
article

Comprehensive Analysis of Genetic Contributions to Alzheimer’s Disease and Frontotemporal Dementia in Admixed Latin American Populations

Nilton Custodio, Teresita Ramos Franco, Stefanie Danielle Piña‐Escudero, Leonel Tadao Takada, María Beatriz Bistué Millón, Pablo Reyes, Agustín M. Ibáñez, Maria Eugenia Godoy, Kenneth S. Kosik, Jared W. Taylor, Elisa de Paula França Resende, María Isabel Behrens, Rosa Montesinos, Carlos Buitrago, Bruce L. Miller, Marcelo Adrián Maito, J. Nicholas Cochran, Jennifer S. Yokoyama, Martín A. Bruno, Andrea Slachevsky, Nancy Gélvez, David Solomon George, Juliana Acosta‐Uribe, Bárbara Bruna, Shireen Javandel, Diana Matallana, Caroline B. Pantazis, Dan Vitale, José Alberto Ávila‐Funes, A. Levine, Luis Ignacio Brusco, Dafne Estefania Durón, Luisa Fernanda Gómez, Greizy López, Lina Maria Zapata‐Restrepo, Andrew Singleton, Caroline Warly Solsberg, Daniela P. Ponce, Mike A. Nalls
article en

Abstract

Our findings represent a pivotal step in understanding the genetic landscape of AD and FTD in admixed populations. They underscore the importance of including diverse populations in genetic research, paving the way for future studies. These findings have the potential to inform more personalized approaches to the diagnosis and treatment of neurodegenerative diseases in diverse global populations, as well as identify novel targets for therapeutic development.

Alzheimer s & DementiaVol. 20(S1)
National Institutes of Health (US), Universidad del Desarrollo (CL), Consejo Nacional de Investigaciones Científicas y Técnicas (AR), University of California, Santa Barbara (US), University of California, San Francisco (US), Trinity College Dublin (IE), Adolfo Ibáñez University (CL), Pontificia Universidad Javeriana (CO), Universidad de Buenos Aires (AR), Clínica Alemana (CL), Universidad de Antioquia (CO), University of San Andrés (AR), Data Tecnica International (United States) (US), Centro Científico Tecnológico - San Juan (AR), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX), Fundación Valle del Lili (CO), Hospital del Salvador (CL), Faculdade de Ciências Médicas de Minas Gerais (BR), National Institute of Neurological Disorders and Stroke (US), Universidad Católica de Cuyo (AR), Hospital Clínico de la Universidad de Chile (CL), Fundación Santa Fe de Bogotá (CO), Institute of Peruvian Studies (PE), National Institute on Aging (US), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), HudsonAlpha Institute for Biotechnology (US), Center for Climate and Resilience Research (CL), Hospital Universitario San Ignacio (CO), Global Brain Health Institute (US), University of Chile (CL), Icesi University (CO)
Openalex Percentile: Top 78%
Biological Research and Disease Studies
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