Differential Roles of Human Tau Isoforms in the Modulation of Inflammation and Development of Neuropathology
This new mouse model of tauopathy better recapitulates the pattern, severity and accumulation of tau and associated neuropathology and behavioral changes observed in human tauopathies such as AD and FTD. This new model should supplant existing single transgenic tau models for validation of therapeutic targets and investigations of novel therapies for ADRD.
Authors
- Dong Yul Sung
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Jennifer Ngolab (ORCID: https://orcid.org/0000-0002-3482-0299)
- Brian Spencer (ORCID: https://orcid.org/0000-0002-7486-1941)
- Aaron Schueler
Institutions
- University of Southern California (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Southern States University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086518
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00