Contributions of heavy metal exposure to late‐onset Alzheimer’s disease
Pb, Cd, and As exposure is common, especially in disadvantaged populations (urban, rural), raising concern about LOAD risk disparities, socioeconomic/racial inequities, and environmental justice. These experiments provide critical feedback related to the impact of the "exposome" in the aging, disease progression, and gene expression of novel preclinical LOAD models. Collectively these data suggest a direct effect of neurotoxicant exposure related to LOAD progression.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Olga Minaeva (ORCID: https://orcid.org/0000-0002-7911-6510)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Juliet A. Moncaster (ORCID: https://orcid.org/0000-0002-7849-4325)
- Bruce T. Lamb (ORCID: https://orcid.org/0000-0001-8507-2561)
- Lee E. Goldstein (ORCID: https://orcid.org/0000-0001-8419-9800)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
Institutions
- Boston University (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091290
- Citations
- 1
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.31