Sex Specific Association of Apolipoprotein E Alleles with Autopsy Measures of Arteriolosclerosis and Atherosclerosis among Older Adults
We provide evidence that the ε4 allele is related to higher levels of arteriolosclerosis and atherosclerosis, while providing modest evidence of a sex difference in the association between the ε2 allele and arteriolosclerosis. Future work will seek to better characterize these sex-specific effects within the context of other neurodegenerative pathologies in the aging brain, and more fully characterize sex-specific clinical consequences of APOE and CVD.
Authors
- Manuel J. Gómez (ORCID: https://orcid.org/0000-0002-4111-4835)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- Sarah Biber
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- David A. Bennett
- Thomas J. Montine
- Matthew S. Panizzon
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- University of Miami (US)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- University of California San Diego (US)
- Dr. John T. Macdonald Foundation (US)
- Rush University (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091485
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00