Isoform‐dependent regulation of Tau function by phosphorylation
Our findings highlight the possibility of differential regulation of Tau isoforms that reflect different roles for Tau in the developing and adult brains. Overall, our findings provide insight into functional regulation of Tau-tubulin/MT interactions by phosphorylation, which is critical for ultimately understanding the significant increase in phosphorylated Tau found in pathology and whether specific phospho-Tau forms can be targeted for therapeutic intervention.
Authors
- Marie Shimogawa (ORCID: https://orcid.org/0000-0002-8471-9375)
- Elizabeth Rhoades (ORCID: https://orcid.org/0000-0002-1741-0650)
- E. James Petersson (ORCID: https://orcid.org/0000-0003-3854-9210)
- Nima Naseri (ORCID: https://orcid.org/0000-0001-8281-219X)
- Ophir Shalem (ORCID: https://orcid.org/0000-0002-2267-0801)
- Tom Tomlinson (ORCID: https://orcid.org/0000-0003-2884-6967)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085651
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00