The role of glial cells in neuroinflammation in the context of Alzheimer’s disease
The results align with a pivotal role of glial cells in AD pathogenesis, showcasing activated glial activity in both in vitro and in vivo models. In the context of chronic processes, these cells may persist in an activated state, releasing cytokines, complement components, and chemokines, potentially contributing to Aβ production and accumulation, thereby exacerbating pathology.
Authors
- Luana Heimfarth (ORCID: https://orcid.org/0000-0002-4503-8905)
- Felipe C. Ribeiro (ORCID: https://orcid.org/0000-0003-3028-3307)
- Sérgio T. Ferreira (ORCID: https://orcid.org/0000-0001-7160-9866)
- Rafaella de Lima Corrêa Ferreira
Institutions
- Universidade Federal do Rio de Janeiro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085661
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.74