The mTOR‐4E‐BP1 axis controls microglia inflammatory and neurodegenerative responses
We demonstrate that mTORC1 signaling critically impacts microglia physiology and promotes neuroprotective functions via 4E-BP1 inhibition. 4E-BP1 activity in microglia engenders a dysfunctional or detrimental state that may lead to increased neurodegeneration. Therefore, 4E-BP1 is an attractive target for microglia modulation in AD.
Authors
- Jung‐Hyun Choi (ORCID: https://orcid.org/0000-0001-6941-463X)
- Niaz Mahmood (ORCID: https://orcid.org/0000-0003-4018-5516)
- Nahum Sonenberg (ORCID: https://orcid.org/0000-0002-4707-8759)
- Sara Bermudez (ORCID: https://orcid.org/0009-0009-0335-4799)
- Luke M. Healy (ORCID: https://orcid.org/0000-0001-9496-2216)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Jo Anne Stratton (ORCID: https://orcid.org/0000-0002-1205-1353)
- Argel Aguilar Valles
- Jacob W. Vogel (ORCID: https://orcid.org/0000-0001-6394-9940)
- Moein Yaqubi (ORCID: https://orcid.org/0000-0001-7299-5930)
- Vivian Yuchan Zhu (ORCID: https://orcid.org/0009-0003-6384-3806)
- Sung‐Hoon Kim (ORCID: https://orcid.org/0000-0002-1570-3230)
Institutions
- University of British Columbia (CA)
- Lund University (SE)
- Science for Life Laboratory (SE)
- Skåne University Hospital (SE)
- McGill University (CA)
- Stony Brook University (US)
- Carleton University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087688
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23